Tite's side have won five out of their five matches since the World Cup, overcoming Uruguay at the Emirates Stadium on Friday.
Having run out emphatic 4-1 winners when the sides last met at the 2014 World Cup, they are clear 1/8 (1.13) favourites with bet365 to extend their run to six consecutive victories in this one.
The Indomitable Lions have won just once in five fixtures following last week's Africa Cup of Nations qualification defeat to Morocco, but are available at 18/1 (19.00) to pull off a shock victory, or 15/2 (8.50) to earn a creditable draw.
The Selecao are expected to ring the changes from the side that beat Uruguay, allowing an opportunity to the likes of Dede, Pablo, Allan, Richarlison and Willian.
Ambroise Oyongo and Petrus Boumal withdrew from Clarence Seedorf's travelling squad through injury, with Wilfrid Kaptoum called in to replace the latter.
While fans in Milton Keynes will be turning up hoping to see a classic example of Brazilian attacking flair, they are more likely to be treated to a master class in defending.
Tite’s men have kept a clean sheet in each of their five recent wins, and conceded a measly total of just eight goals in 31 matches under his command.
Having scored just twice in the last five games against opposition such as Malawi, Comoros and Burkina Faso, it is hard to see Seedorf’s side getting a look-in against such defensive excellence.
With a number of star attackers rested and having no real reason to get out of second gear, odds of 21/20 (2.05) look a smart bet on the South Americans coasting to victory in a match featuring under 3.5 goals for their fifth outing in six.