Sergio Aguero's penalty kick proved decisive as Pep Guardiola's men claimed a 1-0 win against West Ham United on Wednesday evening. It was a nervy night for City and they will face another stiff test against the Cherries at Vitality Stadium.
Eddie Howe's men were thumped 5-1 against Arsenal in north London in midweek, but Bournemouth are at their best on home soil.
City have won eight of their last nine league matches and can be backed at just 1/5 (1.20) to beat Bournemouth.
The Cherries are chalked up as a 12/1 (13.0) chance with bet365 to claim a famous victory against the defending champions. The same firm offer 11/2 (6.50) that both sides settle for a share of the spoils on the south coast.
Bournemouth will again be without Steve Cook, Callum Wilson, David Brooks, Simon Francis and Lewis Cook through injury. Jefferson Lerma completes a two-match ban and is also out.
Fernandinho and Aymeric Laporte remain sidelined for City. Gabriel Jesus and John Stones, too, look likely to sit out again for Guardiola's side.
There have been at least three goals scored in six of City's last eight Premier League matches away from home.
There have been more than two goals in eight of Bournemouth's last 11 matches at Vitality Stadium. Furthermore, the Cherries have failed to score in just two of 18 home matches thus far this term.
Home advantage key
Bournemouth are unbeaten in their last five Premier League fixtures on their own patch. Indeed, the Cherries have scored at least twice in each of their seven home wins in the Premier League this term.
The 9/2 (5.50) quote from bet365 for Bournemouth to score more than one goal could attract support. The same firm offer 9/1 (10.0) that the Cherries score in both halves. Manchester City have conceded in five of their last seven Premier League matches on the road.
There certainly is a compelling case for a goal-laden game at Vitality Stadium on Saturday afternoon. It is worth noting, though, that City have kept four clean sheets in their last five fixtures in domestic competition.
Nevertheless, Guardiola's charges could be pushed hard by the Cherries, who are at their happiest on home soil. The 10/11 (1.91) quote from for both teams to score, therefore, could offer best value for punters ahead of Saturday's showdown.
Odds correct at time of writing. Please gamble responsibly.