Dortmund are one of the favourites to go all the way in this competition, with Peter Stoger's side chalked up as 11/2 (6.50) joint-second favourites to secure the silverware.
With that in mind, it is little surprise that SportPesa make the Germans their 1/2 (1.50) favourites to win on home soil.
Michy Batshuayi is set to start for Dortmund and is a tempting 13/5 (3.60) chance to net first, whilst Shinji Kagawa and Raphael Guerreiro will both miss out through injury.
Salzburg's Munas Dabbur scoring four goals in his last four appearances and is available at 7/1 (8.0) with SportPesa to break the deadlock. Duje Caleta-Car and Fredrik Gulbransen may return to the starting eleven after suspension.
Both teams to score?
Salzburg have scored in seven of their last eight away matches in this competition and SportPesa offer 10/13 (1.77) that there are goals at both ends in this game.
That particular selection that would have landed in four of Dortmund's last five fixtures.
A tight tussle?
There have been fewer than three goals scored in five of the last six matches that Dortmund have played and, so, SportPesa's 23/20 (2.15) quote for no more than two goals to be scored could represent value for punters.
Preview and predictions
Better value, though, could lie in backing classy Dortmund to establish what may prove to be a decisive first leg lead and make it 13 games in a row without defeat.
SportPesa's price of 5/4 (2.25) for Borussia Dortmund to win this one by at least two clear goals could provide punters with a path to profit.