Rotherham can climb out of the relegation zone with a victory and 888Sport offer 9/5 (2.80) that Paul Warne's men come out on top at the New York Stadium.
Wednesday - who are now under the stewardship of Steve Bruce - are narrow favourites at 8/5 (2.60) to pick up their third win in five league games while the draw is the biggest of the match odds quotes at 21/10 (3.10).
That 21/10 (3.10) though, looks to be the way to go for what promises to be a tight, hotly-contested clash between these South Yorkshire sides.
The hosts have seen their last three Championship games end all square while the same is true of Sheffield Wednesday's previous two outings.
Both teams rank in the bottom six for goals scored this campaign. Rotherham have netted just 0.96 times per game on average while the visitors rank only marginally better at 1.09.
With that in mind it's understandable to see the under 2.5 line at just 4/6 (1.67) with 888Sport. Opting for "No" in the both teams to score market returns 10/11 (1.91) if either side fails to find the net.
Such a lack of firepower should only add to the appeal of backing a stalemate though. Combined these teams have played out 23 draws in the second tier so far, that's 36.5 per cent of their league games that have ended all square.
While they're towards the foot of the table, Rotherham have made the New York Stadium a tough place to visit this season. The Millers have only lost at this venue four times in the league and their results against the sides around them add weight to the prospects of a draw.
Of the seven games Warne's men have played at home against teams currently 16th or below in the table, five of them have ended level.
The previous meeting between the pair at Hillsborough ended 2-2 and at 21/10 (3.10) with 888Sport backing this game to finish in a draw looks a solid selection.