After an eye-catching summer in the transfer market, Liverpool are being hotly tipped to end their long wait for a Premier League title this season.
Jurgen Klopp has done some impressive work to strengthen in key areas over the last couple of months, adding Naby Keita, Fabinho, Alisson and Xherdan Shaqiri to a squad that reached the Champions League final last campaign.
Considering their rivals' relative inactivity in the transfer window, it is perhaps no surprise that the Reds are priced at just 4/1 (5.00) with bet365 to bring the title to Anfield for the first time since 1990.
However, this new-look Liverpool team has a considerable amount of ground to make up if they are to close the gap on a Manchester City side they trailed by 25 points last season.
City to dominate again
Having also finished a massive 19 points clear of second place, Pep Guardiola's champions would have to suffer a huge collapse if they were to surrender their title this year.
After adding 2016 Premier League Player of the Year Riyad Mahrez to an already record-breaking attack and with their defence bolstered by January signing Aymeric Laporte and newly fit Benjamin Mendy, the Citizens could instead be stronger than ever.
With this in mind, the smart money may lie in the less exciting 4/6 (1.67) odds available on City achieving back-to-back league wins for the first time in their history.
Spirits are certainly higher at the Etihad Stadium than across town at Old Trafford, where Manchester United have endured a frustrating summer.
Chelsea and United to struggle?
With Jose Mourinho bemoaning the club's failure to bring in his requested transfer targets and a pre-season deprived of most of his key players due to the World Cup, odds of 7/1 (8.00) currently seem rather short on him collecting a Premier League winners' medal next May.
The atmosphere is also less than optimistic at Mourinho's former club Chelsea, where Antonio Conte's drawn out departure has left little time for successor Maurizio Sarri to put his own very different ideas in place.
The former Napoli boss has also not been helped by speculation over the future of key players Thibaut Courtois and Eden Hazard, so it would prove a major shock if the Blues justified their 12/1 (13.00) odds to jump from fifth last season to first this year.
Yet to sign anyone in the transfer window, there is no reason to believe that Tottenham Hotspur can overhaul Manchester City at 14/1 (15.00), while Unai Emery has a lot of rebuilding work to do before he can turn Arsenal 22/1 (23.00) into serious challengers.
Odds correct at the time of writing. Please gamble responsibly.