Barca have won each of their last eight matches in La Liga and bet365 price them at 2/7 (1.28) to extend that winning run.
Valencia beat Villarreal last weekend to record back-to-back La Liga wins for only the second time this season and Los Che are priced at 10/1 (11.00) to earn a third successive win, with the draw offered at 19/4 (5.75).
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Valverde fielded a strong team on Wednesday night in the Copa del Rey and is likely to do so once more on Saturday. Ousmane Demeble remains injured along with Samuel Umtiti and Rafinha. Sergio Busquets is suspended for the champions.
Valencia are missing Geoffrey Kondogbia and Goncalo Guedes through injury while Mouctar Diakhaby is suspended.
After an extremely disappointing opening half of the season, Valencia have seemingly turned a corner.
Having flirted with the relegation battle earlier in the campaign Los Che begin the weekend in seventh place and pushing for a European spot.
Goals have been hard to come by this term for Marcelino Garcia's side, yet at the back they have been solid boasting the second best defensive record in La Liga.
They held Barca to a 1-1 draw at Mestalla back in October and they will be aiming to keep things tight once more this weekend.
Tips and predictions
Under 3.5 goals is offered at 9/10 (1.90) and that looks tempting. This selection has paid out in three of Barca's last four home league games, and in nine of Valencia's ten away matches this term.
Furthermore, this bet has provided a winner in each of the last five meetings between these two sides in all competitions and could be a shrewd option on Saturday at Camp Nou.
Odds correct at time of writing. Please gamble responsibly.