These two teams average the highest possession per game in the Primera Division, with Barca enjoying on average 64 per cent and Betis just behind them at 63 per cent. It should be a fascinating clash with both sides in need of three points.
The Blaugrana are on a 42 match unbeaten run at home in La Liga and William Hill price them at 1/5 (1.20) for another win to stay top of the table.
Betis are winless in their last four league matches and have only won one of their last eight matches on the road in the league. The visitors can be backed at 11/1 (12.00) and the draw at 13/2 (7.50).
Lionel Messi has missed Barca's last five matches, but could return to the bench on Sunday afternoon. Samuel Umtiti and Thomas Vermaelen remain out for the Catalans. Betis are without midfielder Javi Garcia.
Barca's five matches without Messi have seen them produce at least three excellent performances and while the Argentine's brilliance will always be missed, the Blaugrana have enjoyed success in his absence.
Ernesto Valverde's side remain the top scorers in the division while their opponents on Sunday have the worst scoring record on the road, with Betis managing just one goal in their five away league matches this term.
Tips and predictions
The hosts are offered at 23/20 (2.15) to win to nil and given Betis' away form, this bet appeals greatly.
Los Verdiblancos have struggled badly in the final third this season despite enjoying plenty of possession and after a big Europa League game against Milan on Thursday night, Betis might find things tough going at Camp Nou on Sunday afternoon.