Diego Simeone's men have conceded just 13 goals in 20 league games, three fewer than their neighbours, and have had an entire week to prepare after being knocked out of the Copa del Rey last week by Girona.
Getafe were in cup action on Tuesday's evening, beating Valencia 1-0 to continue their excellent recent run.
Pepe Bordalas' side have lost just one of their last 12 matches in all competitions - a 2-1 loss to Barcelona - and boast one of the strongest away records in La Liga, having been unbeaten in such games since the opening day of the season.
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Atletico are suffering from a string of injuries to their squad. Saul Niguez, Stefan Savic, Vitolo, Gelson Martins and Diego Costa are all out with various injuries. Koke and Diego Godin are doubtful and Angel Correa is suspended.
Getafe have no new injury concerns, with forward Amath Ndiaye and midfielder Markel Bergara both long-term absentees.
Atletico boast a fantastic record in this fixture, having won 11 and drawn one of the last 12 league derbies against Getafe, and Los Azulones have not even managed to score a goal against Atletico since 2011 (a run of 15 matches).
This weekend is Getafe's best chance of breaking that goalless streak, having scored in 11 consecutive matches away from home in all competitions.
In Jorge Molina, Angel Rodriguez and Jaime Mata they boast three forwards in-form and capable of causing an injury ridden Atletico side plenty of problems.
Tips and predictions
Opposing a clean sheet for the hosts at evens (2.00) is a tempting option despite Atletico's record in this fixture.
If we think Getafe can score on Saturday, then for higher odds backing them to do so in the second half appeals. The visitors have scored 18 of their 25 league goals in this term after the break, and are priced at 2/1 (3.00) to do so again here.
Odds correct at the time of writing. Please gamble responsibly.