A change of manager has not been enough to bring about a change of fortunes for Sevilla, with the Andalusians slumping to another defeat this weekend in La Liga.
Their 1-0 loss at struggling Alaves means they have picked up just one point from a possible 15 and new coach Vincenzo Montella will hope the Copa Del Rey will provide the catalyst for his tenure.
Sevilla travel to the Wanda Metropolitano to face a rampant Atleti side who sit second in the La Liga table and who have won all four matches they have contested in 2018 without conceding.
Match odds
Paddy Power offer Sevilla at 8/1 (9.00) to become the first Spanish side to win a game at Atleti's new stadium, while Los Rojiblancos are priced at 2/5 (1.40) and the draw can be backed at 10/3 (4.33).
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Team news
Diego Costa was suspended for the weekend win at Eibar in La Liga and the striker should return to a starting eleven which is likely to be close to full strength.
For Sevilla, full-back Sergio Escudero has returned to training having missed Sunday's defeat at Alaves, while centre-back Nico Pareja remains out with a long term injury - although, positively, he has returned to light training this week.
Hosts to continue their winning run
The start of the year has been impressive from Atleti and while Saturday's performance in tough conditions at Eibar was not their best, Diego Simeone's men still ground out a 1-0 win.
That is the kind of the result we have come to expect from Simeone's side and with their opponents badly out of form, Wednesday night is a chance to extend their fine start to 2018.
Sevilla have been extremely poor on the road in La Liga this term, losing seven of their last eight away games, with the Andalusians failing to score in five of those matches.
Tips and predictions
The price of 6/4 (2.50) for Atletico to win 1-0, 2-0 or 3-0 looks tempting and paid out comfortably when the sides met in Madrid in September in La Liga.
Sevilla looked extremely insipid in front of goal against Alaves on Sunday and travelling to face the meanest defence in the Spanish top flight means they could be in for another tough night.
Atletico to win 1-0, 2-0 or 3-0 at 6/4 (2.50) for a 2pt stake with Paddy Power 
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