Diego Simeone's men travel to San Mames to face Athletic Club with the memory of their 3-0 defeat at Juventus still fresh in their minds. However, Barcelona play on Sunday so Los Rojiblancos have a chance to cut the gap at the top to four points.
Despite an indifferent season, Athletic Club remain an extremely difficult to beat in Bilbao. The Basques have only lost two of their 13 home games this term and are unbeaten at San Mames in La Liga since October.
Watch and bet live on Athletic Club vs Atletico Madrid
bet365 customers in the UK can watch and bet live on this fixture. Your account must be funded or active (have placed a bet in the last twenty-four hours) to enjoy the action.
Diego Costa, Thomas Partey, Lucas Hernandez and Filipe Luis all missed Tuesday's trip to Turin, although Costa and Partey were only suspended so should return. Hernandez and Filipe returned to training this week but are injury doubts along with Santiago Arias and Stefan Savic.
Athletic have centre-back Inigo Martinez suspended and striker Aritz Aduriz out injured.
Only two sides have scored fewer than Athletic's total of fourteen home strikes this season and Bilbao has been pretty short on entertainment.
Just 27 goals have been scored at San Mames Stadium this term, one of the lowest totals in the division, and there is every chance that Atletico's visit this weekend will see another goal-shy encounter.
Los Rojiblancos have the best defensive record in the division so they can keep things tight against a low-scoring Athletic team, yet we should not expect them to run riot themselves particularly after one of their most disappointing defeats in recent years.
Tips and predictions
The price of 4/9 (1.44) for under 2.5 goals underlines just what a tight encounter this is expected to be. For higher odds, combining this selection with both teams to score 'no' offers the more appealing price of 4/5 (1.80).
This bet has paid out in six of Atletico's last seven league games and looks a strong option for Saturday's encounter.
Odds correct at the time of writing. Please gamble responsibly.