The Ligue 1 outfit were comfortably the better team at the Stade Velodrome last week and are firm favourites to make it through to the last eight of the competition.
Top scorer Aritz Aduriz, wideman Markel Susaeta and centre back Yeray Alavrez were all rested for Bilbao's win over Leganes at the weekend but should come back in for this fixture.
Marseille winger Florian Thauvin was stretchered off in the first leg with an ankle problem and the French side are waiting to see if he is fit for Thursday night's game.
Athletic's San Mames struggles
The Basques are unbeaten in their last nine home La Liga games, although they have lost two of their last four matches at San Mames in the Europa League.
Their two win homes in Europe this term have been hard fought victories by a single goal margin and the visit of Marseille could be a serious test.
Furthermore, Jose Ziganda's side have played 23 matches in their own stadium this season, but only in four of those games did they achieve a result which would see them progress on Thursday evening.
Tips and predictions
Athletic may have been unimpressive at home in Europe this term, but Marseille have also been underwhelming on the road.
Indeed, the French side have failed to win any of their last seven away games in this competition.
All seven of those away games have seen under 2.5 goals and another repeat looks good value at 17/20 (1.85).