The Gunners suffered a Barcelona-esque scare against CSKA Moscow on Thursday evening after going two goals down on the night, but managed to secure the victory with two late strikes giving them a comfortable aggregate victory.
With their hopes of securing a top-four spot looking extremely unlikely, manager Arsene Wenger could be tempted to field a number of fringe players for the trip to St James' Park on Sunday.
David Ospina has been ruled out for two to three weeks with an ankle injury sustained in training on Wednesday.
Armenia international Henrikh Mkhitaryan also misses out with a slight knee problem and will be missing for a further two weeks.
Spanish midfielder Santi Cazorla remains a long-term absentee with an Achilles injury.
Arsenal would have had Mohamed Elneny suspended for this game following his red card against Southampton although the decision has since been overturned.
Arsenal potential starting line-up
Wenger could rest a number of players with a Europa League semi-final on the horizon.
The likes of Alex Iwobi and Sead Kolasinac could start, while Calum Chambers or Rob Holding will fill in for Laurent Koscielny, with the Frenchman carefully managing his chronic Achilles problem.
Pierre-Emerick Aubameyang is expected to return upfront and could play alongside Welbeck, who has been in electric form of late.
Newcastle team news
Rafael Benitez's side sit mid table in the Premier League with six games of the season left to play. The Spaniard is likely to stick with the 4-4-1-1 formation which has seen his side win three games in a row.
The Magpies boss is likely to field an unchanged XI with Kenedy, Jonjo Shelvey and Dwight Gayle all impressing at the heart of Newcastle's team in recent weeks.
Ayoze Perez is the club's top scorer with six goals to his name so far this season.
Best Opta match facts
Newcastle have lost each of their last 10 Premier League games against Arsenal, since a 0-0 draw in August 2011. Only against Man City (12, 2009-2015) have they had a longer losing streak in top-flight history.
Indeed, Arsenal’s run of 10 wins in a row against the Magpies is their third best winning streak in top-flight history. Only against Man City (11, 1994-2004) and Middlesbrough (11, 1930-1935) have they had longer runs.
The Magpies haven’t won a home league game against Arsenal since December 2005, drawing four and losing five since.
Nine of Arsenal’s 26 Premier League wins against Newcastle have been by a 1-0 score line, including the last three in a row – the most they’ve beaten any other side by that score in the competition.
Pierre-Emerick Aubameyang has scored in each of his last four Premier League games for Arsenal. The last player to score in five in a row for the Gunners was Olivier Giroud in April 2015 (6).
Danny Welbeck’s two goals against Southampton took his tally to five in the Premier League this season – his best return in an Arsenal shirt.
Newcastle haven’t won four straight Premier League games since a run of five in November 2014 under Alan Pardew.
TV channel & kick-off time
The match kicks off at 13:30 BST on Sunday with live television coverage available on Sky Sports in the UK.