The Black Star scored three and assisted another as Chicago Fire thrashed Orlando City 4-0 in Major League Soccer on Saturday.
The 26-year-old becomes the first Ghanaian to record an MLS hat-trick and the seventh Fire player to hit three goals in one game.
“I thought I could do anything on the pitch,” Accam said, according to his club's official website.
“For me, I just wanted to enjoy myself and entertain the fans and also help the team win.
“That’s what we did, especially after my first goal. I just thought I could get more goals and help the team win.
“To be fair, I think this is my first professional hat-trick, so it’s huge for me. I will enjoy it."
Accam's hat-trick, on his 64th MLS appearance, has taken him to 10 league goals and six assists this campaign.
Impressively, with eight matches less, the Accra-born has equalled his best season goal tally since joining Fire in 2015.
The winger is in his last year with Veljko Paunovic's side, having rejected the opportunity to extend his contract which expires at the end of the current campaign.
The former Helsingborg player is expected to join the Black Stars for the upcoming double-header of friendlies against Mexico and the USA on June 28 and July 1 respectively.