In a quirk of the fixture list, AC Milan and Lazio met in Serie A on Sunday - with the Rossoneri triumphing 2-1 at San Siro.
Wednesday night sees the capital return to Milan in the first leg of their Coppa Italia semi final, with Simone Inzanghi's men aiming to take a good result back to Rome.
In Serie A, Milan are currently on their best run of the season with Sunday's success their third successive win.
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Lazio's top scorer Ciro Immobile missed the league game at the weekend with a muscle injury, and remains a doubt here.
For Milan, Nikola Kalinic was not available at the weekend and could be on the bench on Wednesday, while striker Andre Silva could be in line for only his sixth domestic start of the season this term.
Another tight encounter at San Siro
Sunday's game between the sides was a controversial affair, with Patrick Cutrone using his arm to score the opener for Milan - a move not spotted by the VAR officials.
The result ended a run of eight matches unbeaten for the capital club, although they remain third and 12 points above Milan in the table.
Away from home, the Biancazzuri are the top scorers in Serie A, while at San Siro Milan have managed a paltry 11 strikes in 11 league games. There could be some value in backing an away win even without Immobile, although perhaps of more interest should be opposing a high-scoring encounter.
Tips and predictions
A low scoring draw could also be of interest for those looking for a value bet, with under 2.5 goals and draw priced at 3/1 (4.00).