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And Van Gaal admitted that the midfielder is expected to miss the quarter-final meeting with Costa Rica, but is worried that he may not feature again in the tournament.
"De Jong had a small groin strain and I was forced to substitute him," van Gaal explained after the match.
"It's serious. I fear that it's over [for him].
"I don't know if he will be available for the quarter-final, though to be honest it's very unlikely he will be able to play the next match.
"He is one of my most important players, so this is an enormous loss for us."