The Argentine is the heavy favourite to secure the trophy for the fifth time in his career ahead of his rival at Real Madrid and Neymar.
And Wenger, who has previously claimed that individual awards like the Ballon d’Or have the potential to “destroy careers”, believes Barcelona’s haul of five trophies in 2015 should make Messi the winner.
“I’m a big enemy of the Ballon d’Or,” said Wenger.
“It is certainly Messi who will win it, although I’m not a big fan of it.
“It has to be a Barcelona player, when you pick a Barcelona player, it is certainly Messi.”