Walter Mazzarri's side crashed out of the Coppa Italia with a 1-0 defeat at Udinese on Thursday, all-but-ending their hopes of winning a trophy this season.
The Nerazzurri outfit were also beaten by the same scoreline at Lazio in Serie A on Monday night and have now won only two of their last eight games in all competitions, sitting sixth in Serie A.
One positive to take out of Inter's cup defeat was that striker Diego Milito came through his first 90 minutes of the season after recovering from knee and thigh injuries.
Defender Hugo Campagnaro is back in contention for the team 18 points behind table-toppers Juventus after serving a suspension, but in-demand midfielder Fredy Guarin is banned.
Ricky Alvarez, Esteban Cambiasso and Rodrigo Palacio are set to return to the starting line-up after dropping to the bench on Thursday.
Chievo are without a win in three league matches and also exited the Coppa Italia when they were beaten 2-0 at Fiorentina on Wednesday.
Eugenio Corini's side are two points above the relegation zone and were hammered 4-1 at Torino in their last Serie A away game.
Midfielder Luca Rigoni will not feature at San Siro as he serves a suspension.