The terror alert in the Belgian capital Brussels is at the highest level after the government warned of a "serious and imminent" threat of an attack.
Belgian Pro League matches between Lokeren and Anderlecht and Mouscron-Peruwelz and Sporting Charleroi were postponed as a result of the security fears.
Bruges is just over an hour outside of Brussels and the city's mayor has decided no supporters will be in attendance and that no further tickets will be sold for the game at the Jan Breydel Stadion.
Club Brugge's general manager Vincent Mannaert added: "We took into account two scenarios. One where only the visiting fans would be banned, and one where we would have to play in front of an empty stadium.
"We are disappointed that the second scenario has been chosen, which we had not expected. We will now look at what we can do internally in terms of sold tickets, catering et cetera."