West Ham – by virtue of the Fair Play League – will be the first English club to take to the pitch in the 2015-16 campaign, while Southampton will enter in the third play-off round after Arsenal beat Aston Villa to win the FA Cup on Sunday.
The Hammers will discover their fate on June 22, with a number of potential opponents in the pot.
Tottenham and Liverpool – perennial Europa League competitors – will begin in the group stages, with Spurs in pot one and the Reds in pot two.
But when are the draw dates, and who could those flying the flag for the Premier League face? Goal has compiled all of the key dates and the club's potential opponents below!
CHAMPIONS LEAGUE Click here to find out who England's top teams could face
Next season's showpiece takes place in Basel and it looks a long road for the Hammers if they want to make it to the home of the Swiss side – with the managerless Irons facing 22 games in the competition if they are to lift the trophy.
The paths of their Premier League rivals are somewhat shorter, but they could face some tough opposition, with the likes of Schalke, Fenerbahce and Anderlecht all potentially lying in wait.
Tottenham potential group stage opponents | RSC Anderlecht, AZ Alkmaar, Club Brugge, FC Kobenhavn, Besiktas, APOEL, Sparta Prague, Fenerbahce, Standard Liege, Ludogorets, Legia Warsaw, Dinamo Zagreb, Lokomotiv Moscow, Vitoria, Saint-Etienne, FC Augsburg, FC Groningen
Liverpool potential group stage opponents | FC Schalke, Villarreal, Marseille, Sparta Prague, Fenerbahce, Standard Liege, Ludogorets, Legia Warsaw, Dinamo Zagreb, Lokomotiv Moscow, Vitoria, Saint-Etienne, FC Augsburg, FC Groningen
Southampton potential play-off opponents | FC Dinamo Minsk, FK Jablonec, SK Slovan Bratislava, AIK Solna, Neftci PFK, MSK Zilina, FC Aktobe, AEK Larnaca, Go Ahead Eagles, FK Crvena zvezda, Hapoel Kiryat Shmona, FC Shakhtyor Soligorsk, FC Dinamo Tbilisi, ASA Targu Mures
West Ham potential play-off opponents | NK Celje, FC Flora Tallinn, Ferencvarosi TC, Skonto FC, Vikingur, FK Renova, Odds BK, FK Kukesi, Qabala FK, FK Shkendija 79, FC Kairat Almaty, FC Ordabasy Shymkent, MTK Budapest, FC Shirak, Mladost Podgorica, Ulisses FC, FC Saxan, Glentoran FC, VPS Vaasa, FC Dinamo Batumi, Tskhinvali, JK Sillamae Kalev, FC Lusitans, SJK Seinajoki, FC Lahti, Vikingur Reykjavik, FK Jelgava, FK Olimpic Sarajevo, NSI Runavik, UE Sant Julia, FK Atlantas, Glenavon FC, Cork City, FK Kruoja, University College Dublin, SP La Fiorita, AUK Broughton, FK Partizani, FC Progres Niederkorn, FK Trakai, FK Spartaks Jurmala, Balzan FC, Bala Town, AC Juvenes-Dogana, Newton AFC, Alashkert FC, College Europa FC