The hitman had a small stint at the San Siro under Marcello Lippi, but was considered surplus to requirements when Marco Tardelli was brought in to take charge.
Despite having a difficult time playing in Serie A, the Republic of Ireland international has no regrets over his choice to move to Inter from Coventry City 10 years ago.
"I was only a young lad at the time but it's something I will never regret," Keane told Sky Sports News.
"I had a great time over there, I really enjoyed it. They are great people over there so it's something I can look back on, to go over there as a 19-year-old kid and play for one of the biggest clubs in the world, as one of the greatest times in my life and something I will never forget."
Keane added: "[Christian] Vieri, Ronaldo, [Alvaro] Recoba were all there. They were great players and playing with good players every day in training, you obviously learn a lot and I think it really helped me as a player."
Despite going back to his old hunting ground as part of a club that has qualified into the tournament for the first time in almost half a century, the Spurs striker believes that a positive result is in the offing.
"You have to be [at your best]," he said. "If you look at the squad of players we have now, there is no reason why we shouldn't go there and be confident enough to get a result."
However, the 30-year-old is not guaranteed a start, as he has only been a fringe player under manager Harry Redknapp this season.
"It would be a great game to be involved in," he said. "Hopefully I will play some part and it would be nice to score and help us to get a good result."
Keane’s lack of first team football has been highlighted in the latest edition of the Castrol Rankings. The forward has dropped 140 places since last month and is now rated as the 1427th best player currently plying his trade in one of the top five leagues in Europe.
For more Castrol Rankings insights visit the Castrol Zone on Goal.com