Arsenal's impressive 14-game unbeaten run in the Premier League came to an end on Tuesday when Everton beat Arsene Wenger's side at Goodison Park.
The Gunners hadn't lost a league game since the opening day of the season against Liverpool but were killed off by the Toffees in a steely 2-1 victory for Ronald Koeman's men.
How could Man Utd line up?
Sunday's mammoth league clash against Manchester City represents another tough domestic encounter in which Wenger faces a managerial opponent whom he has an indifferent record against.
Wenger will want his side to get back on track with a win at the Etihad Stadium, although he faces a difficult test even though City are missing their top scorer Sergio Aguero through suspension.
Shkodran Mustafi has been ruled out for the rest of the year with a hamstring injury, joining fellow defender Mathieu Debuchy on the sidelines.
German defender Mustafi has been unbeaten in defence since joining the club and his absence could cost the Gunners over a key Christmas period, as their defeat to Everton showed.
Aaron Ramsey and Danny Welbeck are still a week away from returning to full training.
Arsenal have no suspended players for this game.
ARSENAL POTENTIAL STARTING LINE-UP
There's the possibility of Olivier Giroud, Alex Iwobi and Mohamed Elneny coming in if the Arsenal boss is looking to field a more physically dominant team.
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Alex Oxlade-Chamberlain faces the possiblity of being dropped after an underwhelming performance against Everton in midweek, while Gabriel will continue at centre-back due to Mustafi's injury.
MANCHESTER CITY DOSSIER
Manchester City have lost two of their previous five games but Wednesday's win against Watford will have given them a timely confidence boost ahead of the game with Arsenal.
Premier League table
Guardiola's men have been given eight red cards in the Premier League against Arsenal; more than they have against any other opponent and he'll be desperate of seeing no repeat scenes of the recent game with Chelsea which saw City incur a £35,000 fine.
Sergio Aguero is their top goalscorer with 10 goals in the league, but is suspended for the game.
BEST OPTA MATCH FACTS
- The last six Premier League meetings between these two sides have produced 24 goals - four per game, on average.
- Arsene Wenger has won just two of his previous eight competitive meetings with Pep Guardiola (W2 D2 L4), all in the Champions League. Away from home, his record versus the Spaniard is W0 D1 L3.
- Arsenal are the only Premier League side not to be losing at half-time in the Premier League this season (winning seven times, drawing nine times).
TV COVERAGE & KICK-OFF TIME
Kick off is at 4:00pm and live coverage will be available on Sky Sports 1 from 3:30pm.