Yohan Cabaye will not feature for France during the international break having picked up a groin injury.
The midfielder withdrew from Didier Deschamps' squad after picking up the slight injury concern, his club Crystal Palace have confirmed.
Palace were not keen on the 30-year-old doing any further damage to the problem as they prepare to face Middlesbrough after the international round of fixtures.
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France beat Italy 3-1 in a friendly on Thursday and they face Belarus in their first World Cup Qualification game on Tuesday.
Another member of Alan Pardew's squad has also opted out of international duty due to injury, James McArthur pulling out ahead of Scotland's qualifier with Malta.
The 28-year-old has not featured for Palace this term after picking up a knee injury during pre-season, and it is the same problem that has seen him withdraw from Gordon Strachan's squad.
Palace have scored just once in the Premier League this season, in the recent 1-1 draw against Bournemouth, having lost 1-0 to West Brom and Tottenham Hotspur in the two games before that.