Second-half goals from Sammy Ameobi and Ayoze Perez helped Newcastle complete an impressive comeback as Spurs were beaten for the third time at home in the Premier League this term on Sunday.
Emmanuel Adebayor had opened the scoring for Pochettino's side in a first half that Tottenham dominated in large spells and Pochettino was left frustrated by his team's lack of concentration.
"After half-time, within five seconds we concede - it's true, a stupid goal," Pochettino told reporters.
"It was a shock because it all changed in this minute. Six or seven seconds earlier, all was happy in the stadium with a good energy and our supporters were happy and believing we were going to get a good result.
"But in this moment I think it was difficult to manage in our head. Our heads [had] gone and we started to take rash decisions on the pitch and it was difficult. At 2-1, it was difficult.
"It's impossible to go to the pitch and not be ready to play. I think [there was] a lack of concentration from us and we need to work on our mentality because it's not tactical or physical, it's concentration and mentality.
"This is our challenge to improve. It's not easy and we need to be more strong and like a team. We need to speak, to create a different situation on the training ground and work. We know how but you need time to work in this area."
The defeat leaves Tottenham 11th in the Premier League after back-to-back losses, but Pochettino is confident his side can bounce back so long as they exhibit football similar to that on show in the first half.
"I know we lost 2-1 but this is difficult to explain because in the first 45 minutes we played very, very well. I think this was the best 45 minutes we play in the beginning of the season," he added.
"The lack of concentration in the second 45 minutes makes that all change. We need to improve our mentality like a team.
"I am not concerned about the table because we have a lot of time to recover the points. Now, our challenge is improve our mentality, to create a winning mentality."