The Dutch defender, who signed from Vitesse last Tuesday, played the full 90 minutes at left-back in a game which saw Federico Macheda’s double prove decisive.
He was joined in defence by Jonny Evans, who also managed the full match as he continued his recovery from ankle surgery in the summer.
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The Northern Ireland stopper was an unused substitute in the Premier League victory over Fulham at the weekend, which suggests he is nearing full fitness despite Wednesday night’s second string game being his first minutes on the pitch since the final day of last season.
United fans will also have been thrilled to see Darren Fletcher get a full game under his belt for the second successive week. The Scot is making a gradual return to action after a long absence through illness.
The club’s No.2 goalkeeper, Anders Lindegaard, also played, while the Spurs side included starlets Steven Caulker and Harry Kane.
Macheda opened the scoring in fortunate fashion with just 70 seconds on the clock. Ryan Tunnicliffe set the Italian through on goal and when his shot was blocked by Jordan Archer, it rebounded bizarrely back off the striker into the net.
The second goal came on 50 minutes, when another summer addition, Nick Powell, cleverly won a penalty after being brought down by Adam Smith. Macheda stepped up to double United’s advantage.
The visitors got back in the game with 10 minutes to play when Ryan Mason powered in a spot-kick of his own after Kane was fouled by defender Scott Wootton in the area, but the Red Devils held on.
The win was United’s second straight success in the Premier League’s new Under-21 league, which restricts overage outfield players to three per team.
Sir Alex Ferguson was in the stands to watch the game, as was first-team player Tom Cleverley and new Chilean signing Angelo Henriquez.