Following in the footsteps of Gunners legend Ian Wright, who first achieved the feat during the 1996-97 season, the Dutch striker became only the second player to score against 17 different Premier League opponents in a single campaign.
Van Persie has failed to score against only Manchester City and Fulham in 2011-12. He came agonisingly close on two occasions against the former, seeing one strike disallowed for offside at the Etihad Stadium in December before hitting the bar twice in the reverse fixture on Sunday.
It was a similar story against Fulham at the Emirates Stadium in November, Cottagers defender Chris Baird denying Van Persie with a goalline clearance.
|Arsene Wenger confused by FA decisions
Other opponents have had no such luck. Van Persie failed to score in Arsenal's opening two matches as the Gunners were held to a 0-0 draw by Newcastle before suffering a 2-1 defeat at the hands of Liverpool.
The 28-year-old redeemed himself against both teams in March, bagging a stunning double at Anfield before equalising to set Arsenal on their way to victory against the Magpies.
However, his first goal of the season came in miserable circumstances. Manchester United had already scored six and would add two more after Van Persie snatched a consolation effort in the 74th minute in the 8-2 defeat at Old Trafford.
Arsene Wenger would come to rely on his captain during the Gunners' stuttering start to the season. Incredibly, Arsenal did not win a Premier League match without a Van Persie goal until February, when Aaron Ramsey and Thierry Henry helped them to three points.
Fortunately, Van Persie has not struggled to find the scoresheet. After recording a double against Bolton Wanderers in September, the Netherlands international caught fire.
He scored twice in victories over Sunderland and Stoke City before inspiring Arsenal to a remarkable 5-3 triumph over Chelsea by recording two late goals, the first proving the match-winner, to cap off a hat-trick.
A brilliant volley handed the Gunners a 1-0 win against Everton and added to a tally for 2011 that would total 35 goals following the final game of the year against QPR. That record topped Henry's finest 12 months and left Van Persie trailing only Alan Shearer for Premier League goals in a calendar year.
|HE SCORES WHEN HE WANTS?
||Robin van Persie is 2/1 with Paddy Power to score the first goal when Arsenal take on Wigan
After a difficult January, the Arsenal revival began in earnest. Results may have been disappointing in cup competitions, as they suffered defeats at the hands of AC Milan and Sunderland in the Champions League and FA Cup, but Van Persie grabbed another hat-trick against Blackburn Rovers and also scored in the 5-2 mauling of rivals Tottenham.
Six wins in seven since that match have lifted Wenger's team above Spurs in the table and even had goalkeeper Wojciech Szczesny remarking that claiming second place above Manchester City was not beyond the realms of possibility.
Having already faced City and Fulham home and away this season, the Dutchman will not be able to surpass Wright's record.
That assumes, of course, the Premier League's finest goal-poacher will be able to resist the temptation of adding Szczesny to the list of goalkeepers beaten by his shots.
So, if Arsenal establish a comfortable lead on the final day of the season against West Brom, they may well be advised to keep a close eye on their captain.