Reports emerged in Spain this week claiming Atleti had lodged a bid for the Germany winger as they look to bolster their forward line following the sale of Diego Costa and injury to Arda Turan.
However, Gil Marin has made it clear the club are pursuing very different targets to the 25-year-old.
"Reus has never been on Atletico's agenda and his profile does not fit with what the team currently need," he told TVE.
Reus has been the centre of transfer speculation this summer, with reports over a possible bid from Bayern Munich causing friction between the two clubs, despite Pep Guardiola's insistence that he did not deem the player a necessary signing for the German champions.
The attacker has also been linked with a possible switch to the Premier League, with Arsenal and Manchester United credited with an interest.
Reus' current contract with Dortmund expires in 2017.