Late goals from Jan Vertonghen and Fernando Llorente added to Son Heung-min’s earlier strike and gave Spurs a commanding aggregate lead, prompting bet365 to shorten them from 25/1 (26.0).
The scoreline may have flattered Spurs as just five of their 15 shots were on target, whilst at the other end a string of fine saves from Hugo Lloris ensured there was no precious away goal for Dortmund.
Only three teams have ever overturned a three-goal deficit in the second leg of a Champions League tie so Dortmund will join prestigious company if they are able to make it into the quarter-finals.
There was an air of controversy in the first half as Nicolas Tagliafico become the first player in Champions League history to have a goal disallowed by VAR, but Real took full advantage and the aggregate lead.
They are now 9/1 (in from 10/1) with bet365 to lift the trophy for the fourth season in a row, whilst the Amsterdam outfit can be backed at 200/1 (201.0) - although they were 125/1 (126.0) pre-match anyway.
Manchester United’s Champions League dream appears to have all but ended after they lost 2-0 at home to Paris Saint-Germain on Tuesday, putting Ole Gunner Solskjaer’s men all the way out to 125/1 (126.0) from 25/1 (26.0).