Reports emerged in Germany over the past week suggesting the 44-year-old has been identified as a future successor to Jose Mourinho by the Red Devils' hierarchy.
However, the former Porto coach has no desire to encourage the rumours by discussing them in public.
"You know me. I don't talk about that. It does not make sense," he told a news conference when asked if he was flattered by the talk.
"This is not the moment to even think about it. I don't think about it, I totally ignore that, I totally ignore it."
When pressed on whether he would aspire to manage a club like United one day, Nuno replied: "I don't do like that. I go on a daily basis.
"I know what I have to do tomorrow [Saturday]: to prepare the boys well and prepare the team for a tough game against Burnley. This is the way I look at the future. I take it day by day."
The Portuguese manager took charge of the club took charge of Wolves in May 2017, signing a three-year deal.
He then led the club to a spot in the Premier League, achieving promotion with four matches to spare in the Championship season.
Wolves host Burnley on Sunday looking for their second Premier League win of the season.
They then travel to Old Trafford to face United on September 22.