The Kisumu-based Stima are current top of the second tier league on 67 points, six above their weekend opponents who are second on the log.
The ‘Stima Derby’, to be hosted in Kisumu, will highlight the weekend that will see nine matches take place all across the country.
Bottom-placed GFE 105 will also have a chance to fight for their survival in the league when they take FC Talanta at the Camp Toyoyo.
Nakuru All Stars, who are second from the base, will take on Coast Stima at the Afraha Stadium on Saturday.
Saturday fixtures: Nakuru All-Stars vs Coast Stima (Afraha Stadium, 3 pm), Administration Police vs Green Commandos (Camp Toyoyo, 2 pm), FC Talanta vs GFE 105 (Camp Toyoyo, 4.15 pm), Bidco United vs Nairobi Stima (Thika Stadium, 3 pm), Kisumu All Stars vs Migori Youth (Moi Stadium, 3 pm)
Sunday fixtures: Western Stima vs Nairobi City Stars (Moi Stadium, 3 pm), Modern Coast Rangers vs Kibera Black Stars (Mbaraki Grounds, 3 pm), KCB vs Kenya Police (Camp Toyoyo, 2 pm) LIVE on Bamba Sports, Ushuru vs Kangemi All-Stars (Camp Toyoyo, 4.15 pm) LIVE on Bamba Sports