The Catalan parliament plans to hold a referendum on October 1 on whether the region should separate from Spain, although a national court has this week blocked those plans.
But Zidane feels any exit from La Liga would be damaging to the competition, telling a news conference: "I can't see a Spanish league without Barcelona. It's all I can say as a fan of football, of this sport.
"I'm not going to get into it because there are people who want it and people who don't. I simply can't see a Spanish league without them."
Zidane went on to defend comments made by Madrid president Florentino Perez with regard to referees in Spain's top flight.
Perez stated his belief that officials are not operating to the required standard in La Liga and Zidane feels his opinion is justified.
"All Florentino said is that we all have to improve, the referees as well," he said. "The president has the right to say what he thinks and I agree with him, that we all have to improve."