Zinedine Zidane's men take a three-goal lead into the game, having won the first leg 3-0 last week, and with the game well in their favour the French coach is likely to use the opportunity to give game-time to fringe players.
The game would appear to be out of reach for Numancia, but the Segunda Division outfit still have plenty of pride to play for.
|Game||Real Madrid vs Numancia|
|Date||Wednesday, January 10|
|Time||20:30 GMT / 15:30 ET|
|Stream (US only)||fuboTV (7-day free trial)|
TV CHANNEL & LIVE STREAM
The game is not being shown live on television in the United Kingdom, but Goal will be providing updates here .
|US TV channel||Online stream|
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
SQUADS & TEAM NEWS
|Position||Real Madrid players|
|Goalkeepers||Navas, Casilla, Moha|
|Defenders||Theo, Carvajal, Vallejo, Nacho, Achraf, Tejero|
|Midfielders||Kroos, Isco, Ceballos, Casemiro, Llorente, Asensio, Kovacic, Oscar|
Madrid named a 19-man squad for the second leg and it is void of a number of key players, such as Cristiano Ronaldo, Sergio Ramos and Gareth Bale.
However, Toni Kroos and Isco are included, as are Casemiro and Keylor Navas.
Potential Real Madrid starting XI: Casilla; Carvajal, Nacho, Theo, Vallejo; Kroos, Ceballos, Asensio, Isco, Lucas; Majoral.
|Goalkeepers||Munir, A. Fernandez|
|Defenders||Saul, Elgezabal, Calvo, Markel, Gutierrez, Medina|
|Midfielders||Perez, Escassi, Sierra, Mateu, Larrea, Nieto|
|Forwards||Higinio, Nacho, Milla, Guillermo|
Numancia have named an 18-man squad for the game, with Saul Garcia expected to make his debut for the club.
Pape Diamanka, Ripa and Luis Valcarce, who all featured in the first leg, have not been included in the panel for the second leg.
Potential Numancia starting XI: Munir; Saul, Calvo, Medina, Gutierrez; Sierra, Nieta, Larrea, Perez, Milla; Higinio.
BETTING & MATCH ODDS
Unsurprisingly, Real Madrid are heavy favourites to win at 1/7 according to dabblebet, with Numancia rated 16/1. A draw between the teams is considered a 7/1 bet.
Goals from Gareth Bale, Isco and Borja Mayoral gave Real Madrid a comfortable win over Numancia the Nuevo Estadio Los Pajaritos last week, helping to place one foot firmly in the quarter-finals of the competition.
Zidane has opted for a relatively thin 19-man panel for the game, with Bale and Cristiano Ronaldo sitting the game out ahead of the Liga encounter against Villarreal which takes place three days later.
Nevertheless, there is still no shortage of firepower, with Isco set to lead an attack along with the likes of Toni Kroos, Marco Asensio and Mayoral, showing that Madrid are not treating the second leg as a foregone conclusion.
Los Blancos struggled against Celta Vigo in the league on Sunday, allowing victory to slip from their grasp late in the game as they drew 2-2 and Zidane, as well as the fans, will be demanding a much more clinical performance against Numancia, particularly at home.