Orlando Pirates and Kaizer Chiefs don't need any introduction, and while the two teams have been heavily criticised for not doing enough to win whenever they play each other, this year's fixture promises to be an exciting contest.
Goal takes a look at four key battles to look forward to on Saturday afternoon.
SHONGA VS KHUNE
Justin Shonga is oozing with confidence after scoring twice in the previous match against Chippa United, and with this set to be his Soweto Derby debut, he would be eager to score on the afternoon.
He has shown that he's a quality striker with an eye for goal, and scoring against Itumeleng Khune will no doubt do wonders to his self-belief going into the final few games of the season.
However, he will need to box smart against PSL's best keeper, Khune, who has kept a whopping 15 clean sheets in 25 official games for Chiefs this season.
Khune is also an experienced goalkeeper with 25 Soweto Derby appearances under his belt, and he would like to keep his 13th clean sheet in the league by ensuring that no one gets the better of him on the day.
MPHAHLELE VS MEMELA
Rama admitted this week that he hasn't won an official match against Pirates since moving Chiefs, and he expressed his desire to end this record come Saturday.
While his attacking prowess cannot be questioned, the Amakhosi man will have to be wary of Luvuyo Memela, who is arguably one of Bucs' best players this season.
Ramahlwe Mphahlele has the experience, but Memela's strengths include trickery, pace and scoring important goals. It will be interesting to see if Rama will be able to juggle both his defensive and offensive duties when facing an attacking player as good as Memela.
MOON vs MABOKGWANE
If there's anyone Steve Komphela will pin his hopes on for goals, then it has to be Ryan Moon. The young striker has scored five goals in his last seven matches for Chiefs.
He turns half-chances into goals, and with Pirates not really solid defensively, Moon would be licking his lips at the prospect of scoring his first goal against the Buccaneers.
However, Jackson Mabokgwane has raised his game to a level where he's become the Bucs No.1, and he would not want to disappoint on his Soweto Derby debut.
He's also earned the trust of coach Micho Sredojevic in big matches, and for that reason, it would be interesting to see whether Moon will score or Mabokgwane will reign supreme and keep a clean sheet on the day.
MORRISON VS KATSANDE
Bernard Morrison has rediscovered the form that made South African football fans fall in love with his game whilst at AS Vita Club, and he will be key on Saturday.
He creates and scores goals, but of course he will need the help of his teammates to shine on the day because there's a man called Willard Katsande on the Chiefs side.
Katsande usually plays a deeper role and sits just in front of his defence to offer protection, and Komphela will look to him to neutralize every attack, especially from Morrison, who likes to penetrate through the middle.
Morrison has the trickery and pace, but Katsande is a no nonsense midfield kingpin, who tackles everyone and everything in front of him. Hence it has been very difficult for opposition attackers to penetrate through the middle against Chiefs.