The centre-back has joined Die Alte Dame on a season-long loan with an option to buy at the end of the period.
He made 19 Eredivisie outings, involving nine starts, for the Red and Whites in 2017-18 after transferring from AZ Alkmaar in summer last year.
"Hertha have made their fifth signing of the transfer window, taking Derrick Luckassen on a one-year loan from PSV Eindhoven, with an option to buy the player," the Bundesliga outfit announced on their official website on Tuesday.
Luckassen has been forced to pursue a move away from PSV due to his limited appearances last season.
"I was instantly certain that Hertha would be the right step for me. I’d like to win a lot of games with the team and finish as high up as possible on the table," said, the 23-year-old.
"I've been following the Bundesliga for a while, it's a big league. I hope I can play a good role here.
"The atmosphere in the stadiums is great and I am very excited about playing my football and enjoying it here.
"This is only possible through many missions and hard work. I want to win a lot of games with the team and finish as well as possible in the league.
Hertha director of sport Michael Preetz added: “With Derrick’s arrival, we’re getting a player with a very good mentality and who gives us even more options in defence, especially at centre-back.
“He’s been a target of ours for a while now, as his tackling and heading capabilities, as well as his ability to open the game up, fit our play style really well."