In contrast to the West African giants, Iceland will be buoyed heading into this one after holding Argentina in their opening fixture.
However, both sides can take encouragement from the fact that Argentina's thumping defeat by Croatia in their second clash opens the door for either of them to capitalise and take the initiative in the group on Friday.
Will Gernot Rohr stick with the same side that delivered such a lacklustre performance against Croatia, or will he shuffle his pack against Iceland?
Have a go on this Super Eagles squad selector, and let us know who you’d like to see start for Nigeria vs. Iceland, then share your picks on Twitter.
Oghenekaro Etebo may have scored an own goal against Croatia, but he was arguably the Super Eagles' best player in their opener -- impressing both defensively and offensively.
Would you give the star man from the Olympic Games in 2016 a more advanced role against Iceland on Friday.
Similarly, Rohr may be tempted into a reshuffle at full-back -- where Abdullahi Shehu failed to impress -- or up front, where Odion Ighalo struggled to impose himself in the Eagles' opener?
Have a go at the Squad Selector app and let us know how you'd solve these quandries, and how you'd configure a Nigeria midfield which was dysfunctional against Croatia.