The Red Devils have had to contend with Europa League matches all season and played an unusual Thursday night match in the Premier League against their rivals this week.
There will be little time to rest for them as their schedule continues to pile up, and they face a Swans side desperate for any points they can get to boost their survival bid.
|Game||Manchester United vs Swansea City|
|Date||Sunday, April 30, 2017|
|Time||12:00 GMT, 07:00 ET|
TV CHANNEL & LIVE STREAM
In the UK, the match will be available to watch live on television on BT Sport 1 and by stream via the BT Sport app.
|UK TV channel||Online stream|
|BT Sport 1||BT Sport app|
In the US, the match will be available to watch live on television on CNBC and by stream via NBC Sports Live.
|US TV channel||Online stream|
|CNBC||NBC Sports Live|
SQUADS & TEAM NEWS
|Position||Man Utd players|
|Goalkeepers||De Gea, Romero|
|Defenders||Blind, Shaw, Valencia, Darmian, Bailly, Tuanzebe|
|Midfielders||Carrick, Young, Herrera, Lingard, Mkhitaryan, Pogba|
|Forwards||Martial, Rooney, Rashford|
There appears little chance of Chris Smalling and Phil Jones speeding up their returns despite Jose Mourinho's public insistence they should do so, while Marcos Rojo and Timothy Fosu-Mensah are also out at the back.
Zlatan Ibrahimovic has been ruled out for the season and Juan Mata may not play again before the end of the campaign. Paul Pogba will be a doubt again after missing the derby with a hamstring problem and Marouane Fellaini is suspended.
|Goalkeepers||Fabianski, Nordfeldt, Tremmel|
|Defenders||Amat, Naughton, Fernandez, Van der Hoorn, Mawson, Kingsley, Olsson|
|Midfielders||Ki, Britton, Montero, Sigurdsson, Cork, Fulton, Fer, Narsingh, Carroll|
|Forwards||Llorente, Borja, McBurnie, Ayew|
Swansea hope Leroy Fer (dead leg), Martin Olsson (hamstring) and Jack Cork (ankle) will all be available after returning to training, meaning their only definite absentees are Wayne Routledge, Nathan Dyer and Angel Rangel.
BETTING & GAME ODDS
United are strong 2/5 favourites to win at home, according to Oddschecker, with Swansea priced at 9/1 and the draw available at 21/5.
Marcus Rashford is the 4/1 favourite to score first, with Wayne Rooney and Henrikh Mkhitaryan rated at 5/1. Fernando Llorente is the top choice for the visitors at 11/1.
The Manchester derby was going well enough for a depleted United side until Marouane Fellaini's act of stupidity.
It came late enough in the game that the Red Devils left the Etihad Stadium unscathed, but with Paul Pogba's status in doubt and Ander Herrera playing despite being substituted with an ankle problem last weekend, the overall timing of the Belgian's red card and subsequent suspension could not have been much worse.
His absence will likely mean either shifting Henrikh Mkhitaryan or Wayne Rooney into more of a central-midfield role against Swansea City, while Herrera and Michael Carrick will be leaned upon unless Pogba is ready to return.
An inability to rotate is not good news for Jose Mourinho, who still has two routes to the Champions League open - though neither will be easy to navigate - but may find that each is the biggest threat to the other.
United travel to Spain after this to face Celta Vigo in another challenging week, and Paul Clement will be demanding that his relegation-threatened Swans pounce on any signs of weakness they show at Old Trafford on Sunday.