The Portuguese boss makes a single change from the starting XI which beat Stoke City 3-0 on Monday, bringing back Ashley Young at full-back following his three-match ban for an elbow in the midriff of Southampton's Dusan Tadic on December 30.
Young replaces Luke Shaw on the left side of defence, ending the former Southampton defender's five-game run of consecutive starts.
United head for Turf Moor knowing they have a good record away to Burnley over recent history, while they also have a 100 per-cent record in league and cup fixtures so far in 2018 having seen off Everton, Derby County and Stoke without conceding a goal.
However, they go into the fixture still 12 points short of leaders Manchester City in the Premier League table.
Burnley: Pope; Bardsley, Tarkowski, Mee (c), Taylor; Gudmundsson; Defour, Cork, Arfield; Hendrick; Barnes. Subs: Lindegaard, Lowton, Nkoudou, Vokes, Westwood, Wells, K.Long.
Man Utd: De Gea; Valencia (c), Smalling, Jones, Young; Pogba, Matic; Mata, Lingard, Martial; Lukaku. Subs: Romero, Rojo, Rashford, Herrera, Shaw, Fellaini, McTominay.