Joachim Low has unveiled his first Germany squad since the dropping of Jerome Boateng, Thomas Muller and Mats Hummels.
Low announced last week that he had decided to axe Bayern Munich trio Boateng, Muller and Hummels, bringing to an end their international careers.
They all starred as Germany won the World Cup in 2014, although the team as a whole struggled in 2018 as they crashed out of the World Cup before struggling in the Nations League.
The defending champions fell apart in the group stages, failing to advance as they lost to Mexico and South Korea, while the Nations League campaign was far from a rebound as they were relegated after picking up just two points from four matches in a group that included France and Netherlands.
Joshua Kimmich, who is included among the squad, also slammed the decision, saying the dismissal of such respected players was "not okay".
Low says it is his job to give the team a "new face" as Germany look to move on via the introduction of several new faces.
Among them are uncapped trio Lukas Klosterman, Niklas Stark and Maximilian Eggestein, who will be in search of their first cap.
Younger stars like Sane, Kimmich, Kai Havertz, Serge Gnabry and Leon Goretzka are also involved while Neuer, Reus and Toni Kroos lead the old guard.
Captain Neuer, Kroos and Matthias Ginter are the only holdovers from the 2014 squad involved in the latest Germany squad.
Germany will take on Serbia in a friendly on March 20 before facing off with Netherlands four days later in Euro 2020 qualifying.
Germany squad in full:
Goalkeepers: Manuel Neuer, Marc-Andre ter Stegen, Kevin Trapp
Defenders: Matthias Ginter, Marcel Halstenberg, Thilo Kehrer, Lukas Klostermann, Antonio Rüdiger, Nico Schulz, Niklas Stark, Niklas Süle, Jonathan Tah
Midfielders: Maximilian Eggestein, Leon Goretzka, Ilkay Gündogan, Kai Havertz, Joshua Kimmich, Toni Kroos
Forwards: Serge Gnabry, Marco Reus, Leroy Sane, Timo Werner