The Foxes are looking to rediscover the form that saw them win the title in 2015-16, with Craig Shakespeare set to oversee his first full campaign in charge.
LEICESTER CITY INJURIES
After an injury-hit start to the season, Leicester are hopeful that a number of first-team players will be fit enough to make the matchday squad at Old Trafford.
Danny Drinkwater and Robert Huth have returned to full training while Papy Mendy made his first appearance of the campaign off the bench against Sheffield United.
Summer signing Vicente Iborra is also closing in on a return while Jamie Vardy will be fit to start despite limping off late on against Brighton last time out in the Premier League.
The main injury concern for Shakespeare is that of Kelechi Iheanacho, with the new signing from Manchester City struggling with a toe injury.
LEICESTER CITY SUSPENSIONS
No players from either side are suspended for the opening match of the season.
POTENTIAL STARTING LINE-UP
Despite Drinkwater coming into contention, Shakespeare is unlikely to change the team that performed admirably against Arsenal before beating Brighton.
Matty James will again partner Wilfred Ndidi in midfield while Harry Maguire's impressive start to the season means he and Wes Morgan will line up at the heart of the Foxes defence.
MANCHESTER UNITED TEAM NEWS
After two 4-0 wins to open the season, United are unlikely to make many changes with the international break now on the horizon.
Anthony Martial has come off the bench in both games to score and could push Marcus Rashford for a starting berth while Victor Lindelof is still waiting to make his Premier League debut following his summer move from Benfica.
Luke Shaw and Ashley Young both played for the Under-23s during the week but are unlikely to come into consideration for Saturday's match.
BEST OPTA MATCH FACTS
Manchester United have lost just two of their 22 Premier League meetings with Leicester City and only one of these came at Old Trafford: 0-1 in January 1998.
Manchester United, who have won their opening two Premier League games by a four-goal margin, haven’t won three consecutive league games by such a margin or greater since October 1907.
Romelu Lukaku will be looking to become the first Manchester United player to score in each of their opening three Premier League appearances for the club.
Since Craig Shakespeare took charge of his first Premier League game against Liverpool at the end of February, matches involving Leicester City have seen more goals than any other Premier League side — 53 goals in total (29 scored, 24 conceded).
TV COVERAGE & KICK-OFF TIME
The match will be televised in the UK on BT Sport 1 and the US on NBC, with kick-off at 17:30 BST.