The two giants of Spanish football are first scheduled to face off on the weekend of December 20 at Santiago Bernabeu, though that is likely to be rearranged with Madrid competing in the Club World Cup at the same time.
And they will not come face-to-face again in the league until the 36th week of the 38-round campaign when the champions visit Camp Nou on the weekend of May 6.
Zinedine Zidane's Madrid side may have won out in the title race last season, but they did not get their own way when facing their biggest rivals.
They needed a stoppage-time equaliser from Sergio Ramos to secure a draw at Camp Nou, while there was more late drama in the return fixture.
Lionel Messi grabbed a last-minute winner for Barca in the Spanish capital before his now iconic celebration of holding his shirt up to the furious Bernabeu crowd.
The two teams will kick-off their campaigns on the weekend of August 18, with Barca hosting Real Betis and Madrid travelling to Deportivo.