Both teams have made great strides in recent years to establish themselves as fully-fledged members of England’s group of elite clubs.
And on Saturday they lock horns once again as they attempt to underline their respective title credentials.
But how much do you know about this fixture’s recent past?
Did you know that no player has scored more own goals against a single opponent in the Premier League than Jamie Carragher against Tottenham? Okay, but how many?
And how long has it been since the Premier League played host to a couple of superstars who were simultaneously putting up numbers like Harry Kane and Mo Salah?
Take our tricky quiz below and put your knowledge to the test – and then share it with your mates to prove just how much you know ahead of a Premier League mega-fixture.