The decision was taken following the country’s inability to meet up with the required standard for the championship billed to commence in June 2019.
According to Caf president Ahmad Ahmad, the football body will work to ‘determine a new organizing country by the end of the year’.
Ahmad had quelled claims that Cameroon would not be stripped of their hosting rights insisting no country has been penciled down as a replacement.
“But until proven otherwise, I tell you, the Africa Cup of Nations is in Cameroon," Ahmad told Camfoot.
"People talk about what they want. For us, that's it, there is no Plan B so far. Let's be satisfied with that.”
The central African country’s capacity to successfully host an expanded 24-team tournament came under scrutiny after they were initially handed rights to organise the tournament with 16 teams in 2014.