Jose Mourinho's men have not lost in Europe in 2017-18, scoring 10 goals in four games and conceding just once.
United beat Basel 3-0 in the reverse fixture and will hope for a similarly resounding result this time around.
|Game||FC Basel vs Manchester United|
|Date||Wednesday, November 22|
|Time||19:45 GMT / 14:45 ET|
TV CHANNEL & LIVE STREAM
In the United Kingdom (UK), the match will be available to watch live on television on BT Sport 2 and by live stream using the BT Sport app.
|UK TV channel||Online stream|
|BT Sport 2||BT Sport app|
In the United States (US), the match will be available to watch live on television on Fox Sports 2 USA and by live stream using the Fox Soccer Match Pass.
|US TV channel||Online stream|
|Fox Sports 2 USA||Fox Soccer Match Pass|
SQUADS & TEAM NEWS
|Goalkeepers||Vaclik, Salvi, Vailati|
|Defenders||Gaber, Lang, Suchy, Balanta, Riveros, Akanji|
|Midfielders||Buffi, Steffen, Fransson, Serey Die, Elyounoussi, Kutesa, Bua, Calla|
|Forwards||Van Wolfswinkel, Oberlin, Ajeti, Manzambi, Itten|
Basel thumped FC Sion 5-1 at the weekend, and are unlikely to tweak their line-up too much against Jose Mourinho's men.
Former Norwich City striker Ricky van Wolfswinkel is sidelined with an injury, while defender Omar Gaber is a doubt.
Potential Basel starting XI: Vaclik; Lang, Suchy, Akanji, Riveros; Serey Die, Zuffi; Steffen, Elyounoussi, Bua; Ajeti
|Position||Manchester United players|
|Goalkeepers||De Gea, Romero|
|Defenders||Lindelof, Bailly, Jones, Rojo, Smalling, Blind, Shaw, Valencia, Darmian|
|Midfielders||Pogba, Mata, Lingard, Carrick, Young, Herrera, Mkhitaryan, Fellaini, Matic|
|Forwards||Lukaku, Ibrahimovic, Martial, Rashford|
Both Zlatan Ibrahimovic and Paul Pogba returned to action in the club's 4-1 win over Newcastle at the weekend and are in line to play some part against Basel.
Michael Carrick is injured, along with Phil Jones, while Eric Bailly is a doubt.
Potential Real Madrid starting XI: De Gea; Valencia, Smalling, Lindelof, Shaw; Pogba, Matic, Herrera; Mkhitaryan, Lukaku, Martial
BETTING & MATCH ODDS
United are massive favourites and are priced at evens for the win, according to dabblebet, while Basel are priced at 3/1. The draw can be found at 12/5.
United are boosted by the returns of Zlatan Ibrahimovic and Paul Pogba, with both appearing in the resounding 4-1 win over Newcastle at the weekend.
The Red Devils have enjoyed a fine European campaign without the Swede, however, collecting 12 points from a possible 12.
Just one win will see them through to the last 16, and their form thus far suggests that they will secure safe passage to the knockout stages.
Basel, meanwhile, are second in Group A but they sit level on points with CSKA Moscow. The Swiss side hold the head-to-head advantage over CSKA, however, and must merely match their results to qualify for the knockout stages.