Ernesto Valverde's side played out a 2-2 draw with Real Madrid in El Clasico on Sunday and, having already been crowned champions, they will be keen to end the season on a high note.
The Catalan outfit came out on top when they took on Villarreal back in December, winning 2-0 thanks to goals from Luis Suarez and Lionel Messi, so they will be confident in their ability to win.
However, the visitors will also be fired up, since they are currently on a four-match unbeaten run themselves and a positive result could ensure continental football for them next season.
|Game||Barcelona vs Villarreal|
|Date||Wednesday, May 9|
|Time||7pm BST / 2pm ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel & Live Stream
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|beIN Sports||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on Sky Sports Mix and it can be streamed live online using Sky Go.
|UK TV channel||Online stream|
|Sky Sports Mix||Sky Go|
Squads & Team News
|Goalkeepers||Ter Stegen, Cillessen, Ortola|
|Defenders||Semedo, Pique, Alba, Digne, Vidal, Mina, Umtiti, Vermaelen|
|Midfielders||Rakitic, Busquets, D. Suarez, Iniesta, Coutinho, Paulinho, Gomes, Alena|
|Forwards||L. Suarez, Messi, Dembele, Alcacer, Arnaiz|
Sergi Roberto is unavailable due to suspension after being sent off in the Clasico win over Real Madrid. Lucas Digne is an injury concern, while Jose Arnaiz is also out of action.
Potential Barcelona starting XI: Ter Stegen; Semedo, Pique, Umtiti, Alba; Rakitic, Busquets, Coutinho, Dembele; L. Suarez, Messi.
|Goalkeepers||Asenjo, Fernandez, Barbosa|
|Defenders||Gaspar, A. Gonzalez, Semedo, Marin, Ruiz, Costa, Rukavina, Bonera, Torres, Castano|
|Midfielders||Cheryshev, Fornals, Castillejo, Al Dawsari, Trigueroz, Hernandez, Fuego, Soriano, Bruno, Guerra, M. Gonzalez, Garcia, Chuca, Suarez|
|Forwards||Bacca, Unal, Sansone, Martinez, Raba, Poveda|
Villarreal will be without Bruno Soriano, Leandro Suarez and Ramiro Guerra, who are all recovering from knee injuries.
Potential Villarreal starting XI: Asenjo; Rukavina, Ruiz, A. Gonzalez, Gaspar; Cheryshev, Trigueros, Castillejo, Hernandez; Bacca, Raba.
Betting & Match Odds
Unsurprisingly, Barcelona are favourites to win the game, with dabblebet offering odds of 2/7 on the Blaugrana. Villarreal's chances are rated 15/2 and a draw is available at 9/2.
Barcelona are on course for an unbeaten season in La Liga and Villarreal are the first of three remaining opponents they must navigate past if they are to achieve that feat.
With the game coming so soon after the Clasico encounter and the league title already secured, Valverde may opt to switch things up, but the idea of going unbeaten excites him.
"It would be something incredible to be able to get it," Barcelona boss Valverde said of the prospect of lasting a full league season without defeat. "We have to look for incentives and that is important."
Interestingly, Villarreal are set to offer Barca a pasillo or guard of honour before the game as a nod of acknowledgement for their early Liga triumph, which is significant following Madrid's refusal to do so.