The trio started a game together for the first time this season as the Gunners downed the out-of-form Toffees 5-2 , with all three players getting on the scoresheet.
Everton opened the scoring through Wayne Rooney before Arsenal equalised through Nacho Monreal, and from there Arsene Wenger's men well and truly took control of the affair.
Ozil, Lacazette and Aaron Ramsey all found the back of the net in the space of 27 minutes, though Oumar Niasse did pull a goal back for Everton in the third minute of stoppage time.
However, Arsenal were not done there as Alexis netted two minutes later to ensure his side bounced back from their 2-1 loss against Watford in their previous league game in style.
It was not the first time that Arsenal blasted past Everton in the Premier League era, having also beaten the Merseysiders 7-0 in 2005 and 6-1 in 2009.
100 - Arsenal have become the first team to score 100 @PremierLeague goals against a single opponent (Everton). Century.— OptaJoe (@OptaJoe) October 22, 2017
But the north Londoners achieved a league first in their latest victory over Everton by becoming the first side to score 100 goals against a single opponent.
The result has no doubt increased the pressure on Everton boss Ronald Koeman with the Dutchman already under pressure before the game following a poor start to the season in all competitions.
It was, however, a fine day to be an Arsenal fan with supporters no doubt hoping to Alexis, Lacazette and Ozil can now all stay fit and drive their side towards more silverware this season.