Mauricio Pochettino's men can close the gap on leaders Chelsea to a single point - for 72 hours, at least - with a win against the Hammers and the team from north London will certainly come into this clash in confident mood.
Spurs secured a magnificent ninth successive Premier League win by beating Arsenal 2-0 in the north London derby last weekend and Pochettino's charges are chalked up as dabblebet's 2/5 (1.40) favourites to make it a perfect 10 in east London.
Slaven Bilic's side, however, will be determined to spoil the party. West Ham have won two of their last three home fixtures against Spurs in the Premier League and the hosts can be backed at 13/2 (7.50) to take all three points from this tussle, with 7/2 (4.50) that the match ends in stalemate - a selection that would have landed in each of West Ham's last three Premier League matches.
Harry Kane maintained his hugely impressive scoring streak in London derbies with the second goal of the game against the Gunners last weekend; the 23-year-old striker has now scored 24 goals in 32 games against teams from the capital.
Spurs have plenty of quality going forward, but Pochettino's team also boast a solid defensive unit; indeed, the north Londoners have kept a clean sheet in five of their last six Premier League matches.
West Ham have scored just three goals in their last five Premier League games and so the 11/10 (2.10) quote for Spurs to shut out Bilic's men in east London may well prove popular with punters, with 11/8 (2.38) that Tottenham win to nil - a selection that would have landed in each of Spurs' last four league wins.
The home side, though, will feel that they are capable of frustrating the in-form visitors. West Ham have kept a clean sheet in three of their last four Premier League outings, while all but one of the last five meetings between these teams in east London has featured fewer than three goals.
If Spurs are to crank up the pressure on Chelsea, they may have to grind out a positive result and it is the 13/10 (2.30) quote from dabblebet for Friday's fixture to produce fewer than three goals that could offer best value for punters; the selection would have landed in three of West Ham's last four matches, as well as in both of Spurs' last two league wins.