Having now lost just one of their last nine league matches on home turf, they are 31/20 (2.55) favourites with SportPesa to extend their 100 per cent record with another victory.
However, Roy Hodgson's men have not lost a league match at this ground since 2009, and are available at 2/1 (3.00) to make it eight visits without defeat by coming out on top here.
Three of the last four encounters at this stadium have resulted in draws, and you can get odds of 9/4 (3.25) on this one also finishing up all square.
Tom Cleverley, Stefano Okaka, Gerard Deulofeu, Nathaniel Chalobah and Ben Wilmot are all injury doubts for the home team.
Aaron Wan-Bissaka is suspended after getting sent off against Liverpool, while Scott Dann, Jonathan Williams and Connor Wickham remain injured.
Goals at both ends
Despite their poor recent record against this opposition, Javi Gracia's team will be in confident spirits after making their best start to a top-flight season since 1982.
Having failed to score in just one of their last 15 league matches in their own back yard, the hosts look more than likely to give the crowd yet more to cheer about in this clash.
However, the Eagles have also scored in all but one of their previous 12 league games on the road, albeit conceding in eight of the most recent 11.
All in all, odds of 91/100 (1.91) look generous on goals going in at both ends for the fifth game in seven between Watford and Palace on Sunday.