The home side led 2-0 for the majority of the match after first half strikes from Timo Werner and Leroy Sane, only for Quincy Promes and Virgil van Dijk to strike late on to level the scores and send the Oranje through to the Nations League finals.
Low’s side are yet to win a competitive match since their dramatic victory over Sweden during the World Cup group stages and registered just two points in their Nations League group.
The Germany boss, who remains the longest serving European national team manager as it stands, spoke of his frustration at full time after his side failed to kill the game.
"I am a little disappointed with the result. When I see the whole season, I have seen more positive than negative,” Low said.
“In the end we were punished, that is of course bitter. It was clear that Holland throws everything forward. That's the price you sometimes have to pay because we have a young team.
“We have to learn to bring a 2-0 home. These are empirical values that still have to be collected."
RB Leipzig forward Werner, who scored Germany’s opener and was one of their better performers on the night, was also downbeat following the match and said the result epitomised what has been a hugely disappointing year for the 2014 World Cup winners.
"It is a pity. We had everything under control until the 1-2 and chances to make the game even clearer,” Werner explained.
“Then we get a stupid goal against us - and that we get even and the 2-2 is bitter.
“If you play as we do today, you can not give away a lead five minutes before the end.
“The game showed what happened in 2018. We saw that it worked - and in the end things went wrong again.”
Midfielder Toni Kroos set up Germany’s second goal with an excellent pass through to Manchester City winger Sane, who eventually finished past Oranje goalkeeper Jasper Cillessen.
The Real Madrid star believes his side were made to pay for not adding a third goal before Netherlands’ forged a comeback.
"It is bitter because we did not decide on the game,” Kroos said.
“We had a to score the third goal. If we do that, the game is over, I think everyone on the pitch felt it was good before, we did it well, but now the result stays."
The draw was Germany’s final match of 2018 and it remains to be seen whether Low will be in charge for the upcoming set of international fixtures next March.