Whilst Spurs' Premier League title aspirations have been effectively ended thanks to just one point from their last three matches, the north Londoners will be in good spirits after a emphatic 4-0 aggregate win against Borussia Dortmund in the Champions League on Tuesday.
Southampton, meanwhile, are just two points clear of the relegation zone. With just one win in their last six matches, results must improve soon if the Saints are to survive.
Southampton can be backed at 16/5 (4.20) with SportPesa to ease their relegation worries with a win against Spurs. Mauricio Pochettino's men are available at 5/6 (1.83) to pile yet more pressure on the Argentine's former employers with victory here.
SportPesa offer 53/20 (3.65) that both sides are forced to settle for a share of the spoils on Saturday afternoon.
Danny Ings and Mario Lemina face a race to be fit for the hosts this weekend. Michael Obafemi will not feature again this season.
Eric Dier and Dele Alli could return to the starting line-up for Spurs at St Mary's. Kieran Trippier could also come back in this weekend after missing the trip to Germany. Harry Winks is rated as doubtful after limping off against Dortmund.
Southampton have scored in each of their last 10 home matches in all competitions but defensive frailty has been their undoing. Indeed, Southampton's clean sheet against Fulham last month was their first at St Mary's since October.
Spurs struggling on the road
Tottenham have lost each of their last four fixtures away from home in domestic competition and SportPesa offer 21/20 (2.05) that the Saints avoid defeat at St Mary's. The same firm go 11/5 (3.20) that Pochettino's men concede at least twice.
Spurs have shipped two goals in each of their last four fixtures on the road against English opposition. Tottenham, however, could draw confidence from their hugely impressive 1-0 win against Dortmund in Germany on Tuesday night.
There is plenty of potential for goals, then, ahead of Saturday's showdown at St Mary's. SportPesa offer a tempting 23/20 (2.15) that there are least three goals - with goals at both ends - when these teams lock horns.
With both sides desperate for a positive result, it is a play that could represent real value for punters this weekend.