Many Owls fans were content to see the former head coach leave but they have since seen their side register just two wins.
Swansea, meanwhile, have won six in 11 in all forms under the Portuguese's tutelage.
Wednesday are 23/10 (3.3) with Betfair Sportsbook to secure victory in 90 minutes and reach the quarter-finals for the first time since 1996-97.
Among a long list of absentees for the hosts is Sam Hutchinson, Fernando Forestieri and Gary Hooper.
Swansea’s Wilfried Bony and Leroy Fer are out for the season, so Tammy Abraham is in line to start after netting twice in the 8-1 victory over Notts County in the fourth round replay.
Siding with the Swans
While survival remains the Welsh club’s main priority, this is their only fixture in a 14-day period so fitness problems or wholesale changes are unlikely.
Sheffield Wednesday are facing a busier period so it makes sense to go with the visitors, who are 4/5 (1.8) to score first or 7/2 (4.5) to win with the -1 handicap - which will land if they triumph by two or more goals.
Tips and predictions
The value is very much with Swansea here and for our best bet, we’re taking the 15/8 (2.88) on them winning with Ooer 1.5 goals.
This selection will come off should they reach the quarter-finals with victory inside 90 minutes by a scoreline other than 1-0.
New customer offer. Place 5 x €10 or more bets to receive €20 in free bets. Repeat up to 5 times to receive maximum €100 bonus. Min odds 1/2 (1.5). Exchange bets excluded. T&Cs apply.Swansea to win with Over 1.5 goals 15/8 (2.88) for a 1pt stake with Betfair