Twelve months ago, the Italians triumphed 3-2 in New Jersey while this year's contest takes place at the other end of the country in San Diego.
Spurs' squad for the tour is missing some of their biggest names who were all involved in the latter stages of the World Cup, with a total of nine first-team players all missing.
The likes of Harry Kane, Hugo Lloris, Toby Alderweireld and Jan Vertonghen have all been given time off to recover so will not feature in California.
Roma had fewer members of the squad involved at the World Cup, with Aleksandar Kolarov and Federico Fazio both rejoining the squad already after the tournament.
New signings Javier Pastore and Justin Kluivert have already featured in pre-season and will be aiming to pick up more minutes.
Roma have already played two friendlies against lower league Italian opposition, while this will be the first game of the summer for Mauricio Pochettino's side.
Missing a host of first choice players, it is likely that the Spurs' starting eleven will have an extremely young feel to it with ten youth prospects from the Spurs' academy having made the trip to the USA.
It is probable that Roma field a much stronger team than their English opponents, and that is why the Italians are slight favourites.
Tips and predictions
Roma are offered at 11/4 (3.75) to win and concede and that could be an attractive option for the game.
Spurs have scored but lost in both of the matches they have previously played against Italian opposition in the International Champions Cup, and this looks like an interesting selection for a value bet.